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张大兵
发表时间:2013-07-02 阅读次数:5932次

 

主要经历:

1991年-1994年:南京大学生物系植物学专业获硕士学位;

1994年-1998年:中国科学院上海植物生理生态研究所获得植物分子遗传学博士学位;

1998年-2005年:上海市农业科学院,生物技术研究中心,植物分子生物学实验室主任、助理研究员、副研究员、研究员;

2005年-至今:上海交通大学,生命科学技术学院,教授、特聘教授,发育生物学学科带头人;国家杰出青年基金获得者(2007年)、教育部长江学者奖励计划特聘教授(2009年)、上海市优秀学科带头人(2007年)和国家百千万人才工程入选者(2009年)、上海科技启明星、上海市曙光学者、教育部新世纪优秀人才等。

 

学术兼职:

1) 国际标准化组织ISO/TC34/SA16工作组专家(2010年-现在);

2) 国家农业转基因生物安全委员会委员(2004年-现在);

3) 中国植物生理与分子生物学学会、上海市生物化学与分子生物学学会理事等;

4) Journal of Integrative Plant Biology (2006 –现在)、Journal of Plant Physiology (2007–现在)、Journal of Genetics & Genomics(2009–现在)、Journal of Plant Biology (2011-现在)、Biotechnology Advance (2012-现在)、Planta (2012-现在)期刊的编委。

5)Faculty member of Faculty 1000 (2013年-现在)。

 

研究方向:

1)水稻花序和花器官形态建成的分子调控机理研究:水稻具有特殊的花序和花器官结构,决定粮食产量,利用遗传学、生物化学、细胞生物学等手段研究MADS-box等转录因子参与水稻花序和花器官形态建成。

2)水稻雄性生殖发育机理研究:植物雄性生殖器官花药发育以及雄性生殖细胞花粉的形成对于植物孢子体和配子体世代交替、遗传和变异等非常重要,涉及细胞分裂、分化、细胞和细胞之间交流、细胞死亡以及减数分裂、有丝分裂等重要生物学过程。我们利用系统生物学(基因组、蛋白组、代谢组等)、遗传学、细胞生物学、生物化学、结构生物学等手段研究控制水稻生殖发育的细胞和细胞之间通讯、细胞程序性死亡、脂类代谢等重要分子机制。

3)转基因生物分子特征研究:利用系统生物学手段研究转基因生物在基因组、转录组、蛋白组、代谢组变化规律,建立转基因生物分子特征检测监测新方法,制订相关技术标准。

 

发表论文:

1. Niu NN, Liang WQ, Yang XJ, Jin WL, Wilson ZA, Hu JP, Zhang DB*. EAT1 promotes tapetal cell death by regulating aspartic proteases during male reproductive development in rice. Nature Communications. DOI: 10.1038/ncomms2396.

2. Zhang H, Xu C, He Y, Zong J, Yang XJ, Si HM, Sun ZX, Hu JP, Liang WQ, Zhang DB*. Mutation in CSA creates a new photoperiod-sensitive genic male sterile line applicable for hybrid rice seed production. PNAS. 110(1) (2013), 76-81.

3. Tan HX, Liang WQ, Hu, JP Zhang DB*. MICROSPORE AND TAPETUM REGULATOR 1 encodes a secretory fasciclin glycoprotein required for male reproductive development in rice. Developmental Cell. 22(6) (2012), 1127-1137.

4. Wang CM, Marshall A, Zhang DB, Wilson ZA*, ANAP: an integrated knowledge base for Arabidopsis protein interaction network analysis. Plant Physiology. 158(4) (2012), 1523-1533.

5. Li W, Cui X, Meng ZL, Huang X, Xie Q, Wu H, Jin HL, Zhang DB, Liang WQ*, Transcriptional regulation of Arabidopsis MIR168a and ARGONAUTE1 homeostasis in ABA and abiotic stress responses. Plant Physiology. 158(3) (2012), 1279-1292.

6. Chen WW, Yu XH, Zhang K, Shi JX, Schreiber L, Shanklin J, Zhang DB*, Male Sterile 2 encodes a plastid-localized fatty acyl ACP reductase required for pollen exine development in Arabidopsis thaliana. Plant Physiology. 157(2) (2011), 842-853.

9. Li HF, Liang WQ, Hu Y, Zhu L, Yin CS, Xu J, Dreni L, Kater MM, Zhang DB*, Rice MADS6 interacts with the floral homeotic genes SUPERWOMAN1, MADS3, MADS58, MADS13, and DROOPING LEAF in specifying floral organ identities and meristem fate. The Plant Cell. 23(7) (2011), 2536-2552.

10. Shi J, Tan HX, Yu XH, Liu YY, Liang WQ, Ranathunge K, Franke RB, Schreiber L, Wang YJ, Kai GY, Shanklin J, Ma H, Zhang DB*, Defective Pollen Wall (DPW) is required for anther and microspore development in rice and encodes a fatty acyl ACP reductase. The Plant Cell. 23(6) (2011), 2225-2246.

11. Li H, Yuan Z, Vizcay-Barrena G, Yang CY, Liang WQ, Zong J, Wilson Z, Zhang DB*. PERSISTENT TAPETAL CELL 1(PTC1) encodes a PHD-finger protein that is required for tapetal cell death and pollen development in rice. Plant Physioloy. 156(2) (2011), 615-630.

12. Li HF, Liang WQ, Yin CS, Zhu L, and Zhang DB*. Genetic interaction of OsMADS3, DROOPING LEAF and OsMADS13 in specifying rice floral organs identities and meristem determinacy. Plant Physioloy. 156(1) (2011), 263-247.

13. Wang CM and Zhang DB*.A novel compression tool for efficient storage of genome resequencing data. Nucleic Acids Research. 39(7) (2011), e45.

14. Hu LF, Liang WQ, Yin CS, Cui X, Zong J, Wang X, Hu JP and Zhang DB*. Rice MADS3 regulates ROS homeostasis during late anther development. The Plant Cell. 23(2) (2011), 515-533.

15. Zhang Z, Zhang Y, Tan HX,Wang Y, Li G, Liang WQ, Yuan Z, Hu JP, Ren HY, and Zhang DB*. RICE MORPHOLOGY DETERMINANT encodes the type II formin FH5 and regulates rice morphogenesis. The Plant Cell. 23(2) (2011), 681-700.

16. Xu J, Yang CY, Yuan Z, Zhang DS, Gondwe MY, Ding ZW, Liang WQ, Zhang DB*, and Wilson ZA.Regulatory network ofABORTED MICROSPORES (AMS) required for postmeiotic male reproductive development in Arabidopsis thaliana. The Plant Cell. 22(1) (2010), 91-107.

17. Wang CM, Xu J, Zhang DS, Wilson ZA, and Zhang DB*. An effective approach for identification of in vivo protein-DNA binding sites from paired-end ChIP-Seq data. BMC Bioinformatics. 11 (2010), 81.

18. Li H, Pinot F, Sauveplane V, Werck-Reichhart D, Diehl P, Schreiber L, Franke R, Zhang P, Chen L, Gao YW, Liang WQ, andZhang DB*. CYP704B2 catalyzing the ω-hydroxylation of fatty acids is required for anther cutin biosynthesis and pollen exine formation in rice. The Plant Cell. 22(1) (2010), 173-190.

19. Li H, and Zhang DB*. Biosynthesis of anther cuticle and pollen exine in rice. Plant Signaling & Behavior. 5(9) (2010), 1121-1123.

20. Li HF, Liang WQ, Jia RD, Yin CS, Zong J, Kong HZ, and Zhang DB*. The AGL6-like gene OsMADS6 regulates floral organ and meristem identities in rice. Cell Research. 20(3) (2010), 299-313.

21. Hu LF, Tan HX, Liang WQ, and Zhang DB*. The Post-meiotic Deficient Anther1 (PDA1) gene is required for post-meiotic anther development in rice. Journal Genetics Genomics. 37(1) (2010), 1-10.

22. Zhang H, Liang WQ, Yang XJ, Luo X, Jiang N, Ma H, and Zhang DB*. Carbon Starved Anther (CSA) encoding a MYB domain protein regulates sugar partitioning required for rice pollen development. The Plant Cell. 22(3) (2010), 672-689.

23. Zhang X, Zong J, Liu JH, Yin JY and Zhang DB*. Genome-wide analysis of WOX gene family in rice, sorghum, maize,Arabidopsis and poplar. Journal of Integrative Plant Biology. 52 (11) (2010), 1016-1026.

24. Zhang DS, Liang WQ, Yin C, Zong J, Gu F, and Zhang DB*. OsC6, encoding a lipid transfer protein (LTP), is required for postmeiotic anther development in rice. Plant Physiology. 154(1) (2010), 149-162.

26. Liu ZH, Bao WJ, Liang WQ, Yin JY, and Zhang DB*. Identification of gamyb-4 and analysis of the regulatory role of GAMYB in rice anther development. Journal of Integrative Plant Biology. 52(7) (2010), 670-678.

27. Gao XC, Liang WQ, Yin CS, Ji SM, Wang HM, Su X, Guo CC, Kong HZ, Xue HW, Zhang DB*. The SEPALLATA-like gene OsMADS34 is required for rice inflorescence and spikelet. Plant Physiology. 153(2) (2010), 728-740.

29. Guan XY, Guo JC, Shen P, Yang LT, and Zhang DB*, Visual and rapid detection of two genetically modified soybean events using Loop-mediated Isothermal Amplification method, Food Analytical Methods. 3(4) (2010), 313-320.

30. Liu DE, Shen J, Yang LT, Zhang DB*. Evaluation of the impacts of different nuclear DNA content in the hull, endosperm, and embryo of rice seeds on GM rice quantification. Journal of Agriculture Food Chemistry. 58(8) (2010), 4582-4587.

31. Wang C, Jiang LX, Rao J, Liu YN, Yang LT, Zhang DB*. Evaluation of four genes in rice for their suitability as endogenous reference standards in quantitative PCR. Journal of Agriculture Food Chemistry. 58(22) (2010), 11543-11547.

33. Wei JL, Xu M, Zhang DB*, and Mi HL*. The role of carotenoid isomerase in maintenance of photosynthetic oxygen evolution in rice plant. ActaBiochimica et BiophysicaSinica. 42(7) (2010), 457-63.

34. Yuan Z, Gao S, Xue DW, Luo D, Li LT, Ding SY, Yao X, Wilson ZA, Qian Q, and Zhang DB*. RETARDED PALEA1 (REP1) controls palea development and floral zygomorphy in rice. Plant Physiology. 149(1) (2009), 235-244.

35. Zhang DB*, and Wilson ZA. Stamen specification and anther development in rice. Chinese Science Bulletin. 54(14) (2009), 2342-2353.

36. Wilson ZA*, and Zhang DB. From Arabidopsis to rice, pathways in pollen development. Journal of Experimental Botany. 60(5) (2009), 1479-1492.

37. Zong J, Yao X, Yin JY, Zhang DB* and Ma H*. Evolution of the RNA dependent RNA polymerase (RdRP) genes, duplications and possible losses before and after the divergence of major eukaryotic groups. Gene. 447(1) (2009), 29-39.

38. Guo JC, Yang LT, Liu X, Zhang HB, Qian BJ, and Zhang DB*.Applicability of the Chymopapain gene used as endogenous reference gene for transgenic Huanong No,1 papaya detection. Journal of Agriculture Food Chemistry. 57(15) (2009), 6502-6509.

43. Guo JC, Yang LT, Liu X, Guan XY, Jiang LX, and Zhang DB*. Characterization of the exogenous insert and development of event-specific PCR detection methods for genetically modified Huanong No, 1 papaya. Journal of Agriculture Food Chemistry. 57(16) (2009), 7205-7212.

44. Jiang LX, Yang LT, Zhang HB, Guo JC, Marco M, Van den EG, and Zhang DB*. International collaborative study of the endogenous reference gene, Sucrose Phosphate Synthase (SPS), used for qualitative and quantitative analysis of genetically modified rice. Journal of Agriculture Food Chemistry. 57(9) (2009),3525-3532.

45. Yang LT, Zhang HB, Guo JC, Pan LW, and Zhang DB*. International collaborative study for the endogenous reference gene,LAT52, used for qualitative and quantitative analysis of genetically modified tomato. Journal of Agriculture Food Chemistry. 56(10) (2008), 3438-3443.

50. Dong W, Yang LT, Shen KL, Kim BH, Kleter GA, Marvin HJP, Guo R, Liang WQ, and Zhang DB*. GMDD, a database of GMO detection methods. BMC Bioinformatics. 9 (2008), 260.

51. Yang LT, Liang WQ, Jiang LX, Li WQ, Cao W, Wilson ZA, and Zhang DB*, A novel universal real-time PCR system using the attached universal duplex probes for quantitative analysis of nucleic acids. BMC Molecular Biology. 9 (2008), 54.

52. Zhang DS, Liang WQ, Yuan Z, Lia N, Shi J, Wang J , Liu YM, Yu WJ, and Zhang DB*. Tapetum Degeneration Retardation is critical for aliphatic metabolism and gene regulation during rice pollen development. Molecular Plant. 1(4) (2008), 599-610.

53. Yang LT, Guo JC, Pan AH, Zhang HB, Zhang KW, Wang ZM, and Zhang DB*. Event-specific quantitative detection of nine genetically modified maizes using one novel standard reference molecule. Journal of Agriculture Food Chemistry. 55(1) (2007), 15-24.

54 Shi XZ, Wu AB, Qu GR, Li RX, and Zhang DB*. Development and characterisation of molecularly imprinted polymers based on methacrylic acid for selective recognition of drugs. Biomaterials. 28(25) (2007), 3741-3749.

55. Chu HW, and Zhang DB*. The shoot apical meristem size regulated by FON4 in rice. Plant Signaling & Behavior, 2(2) (2007), e1-e2.

56. Li N, Zhang DS, Liu HS, Yin CS, Li XX, Liang WQ, Yuan Z, Xu B, Chu HW, Wang J, Wen TQ, Huang H, Luo D, Ma H, and Zhang DB*.The rice Tapetum Degeneration Retardation gene is required for tapetum degradation and anther development. The Plant Cell. 18(11) (2006), 2999-3014.

57. Chu HW, Qian Q, Liang WQ, Yin CS, Tan HX, Yao X, Yuan Z, Yang J, Huang H, Luo D, Ma H, and Zhang DB*. The FLORAL ORGAN NUMBER4 gene encoding a putative ortholog of Arabidopsis CLAVATA3 regulates apical meristem size in rice. Plant Physiology. 142(3) (2006), 1039-1052.

58. Li XX, Duan XP, Jiang HX, Sun YJ, Tang YP, Yuan Z, Guo JK, Liang WQ, Chen L, Wang J, Ma H, Yin JY, and Zhang DB*. Genome-wide analysis of basic/helix-loop-helix transcription factor family in rice and Arabidopsis. Plant Physiology. 141(4) (2006), 1167-1184.

59. Jiang DH, Yin CS, Yu AP, Zhou XF, Liang WQ, Yuan Z, Xu Y, Yu QB, Wen TQ, and Zhang DB*.Duplication and expression analysis of multicopymiRNA gene family members in Arabidopsis and rice. Cell Research. 16(5) (2006), 507-518.

60. Qian BJ, Shen HF, Xiong JJ, Chen L, Zhang L, Jia JW, Wang Y, Zhang ZC, Yuan Z, Cao KM, and Zhang DB*. Expression and purification of the synthetic preS1 gene of Hepatitis B Virus with preferred Escherichia coli codon preference. Protein Expression and Purification. 48(1) (2006), 74-80.

61. Yang LT, Pan AH, Zhang KW, Yin CS, Qian BJ, Chen JX, Huang C, and Zhang DB*.Qualitative and quantitative PCR methods for event-specific detection of genetically modified cotton Mon1445 and Mon531. Transgenic Research. 14(6) (2005), 817-831. (*通讯作者).

62. Yang LT, Pan AH, Zhang KW, Guo JC, Yin CS, Chen JX, Huang C, and Zhang DB*. Identification and quantification of three genetically modified insect resistant cotton lines using conventional and TaqMan real-time polymerase chain reaction methods.Journal of Agriculture Food Chemistry. 53(16) (2005), 6222-6229.

63.Yang LT, Chen JX, Huang C, Jia SR, Liu YH, Pan LW, and Zhang DB*. Validation of a cotton specific gene, Sad1, used as an endogenous reference gene in qualitative and real-time quantitative PCR detection of transgenic cottons. Plant Cell Reporter. 24 (4) (2005), 237-245.

64.Yang LT, Xu SC, Pan AH, Yin CS, Zhang KW, Wang ZY, Zhou ZG, and Zhang DB*. Event-specific qualitative and quantitative PCR detection of genetically modified MON863 maize based on the 5’-transgene integration sequence. Journal of Agriculture Food Chemistry. 53(24) (2005), 9312-9318.

65.Weng HB, Yang LT, Liu ZL, Ding JY, Pan AH, and Zhang DB*.A novel reference gene, High-mobility-group protein I/Y,can be used in qualitative and real-time quantitative PCR detection of transgenic rapeseeds.Journal of AOAC International. 88(2) (2005), 577-584.

66.Yang LT, Ding JY, Zhang CM, Jia JW, Weng HB, Liu WX, and Zhang DB*.Estimating the copy number of transgenes in transformed rice by real-time quantitative PCR. Plant Cell Reporter. 23(10-11) (2005), 759-763.

67. Yang LT, Pan AH, Jia JW, Ding JY, Chen JX, Huang C, Zhang CM, and Zhang DB*.Validation of a tomato specific gene,LAT52, used as an endogenous reference gene in qualitative and real-time quantitative PCR detection of transgenic tomatoes.Journal of Agriculture Food Chemistry. 53(2) (2005), 183-190.

68. Liu HS, Chu HW, Hui Li, Wang HM, Wei JL, Li N, Ding SY, Huang H, Ma H, Huang CF, Luo D, Yuan Z, Liu JH, and Zhang DB*. Genetic analysis and mapping of rice (Oryza sativa L,) male-sterile (OsMS-L) mutant. Chinese Science Bulletin. 50(2) (2005) ,122-125.

69. Li H, Xu L, Wang H, Yuan Z, Cao XF, Yang ZN, Zhang DB, Xu Y, and Huang H*, The Putative RNA-dependent RNA polymerase RDR6 acts synergistically with ASYMMETRIC LEAVES1 and 2 to repress BREVIPEDICELLUS and MicroRNA165/166 in Arabidopsisleaf development. The Plant Cell, 17(8) (2005), 2157-2171.

70. Ding JY, Jia JW, Yang LT, Wen HB, Zhang CM, Liu WX, and Zhang DB*.Validation of a rice specific gene, Sucrose Phosphate Synthase, used as the endogenous reference gene for qualitative and real-time quantitative PCR detection of transgenes. Journal of Agriculture Food Chemistry. 52(11) (2004), 3372-3377.

71. Weng HB, Pan AH, Yang LT, Zhang CM, Liu ZL,and Zhang DB*.Estimating transgene copy number by real-time PCR assay using HMG I/Y as an endogenous reference gene in transgenic rapeseed. Plant Molecular Biology Reporter. 22(3) (2004), 289-300.

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